Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
Joint Authors
Zhang, Jian
Xu, Xun
Feng, Kai-Yan
Chen, Lei
Jiang, Min
Cai, Yu-Dong
Yuan, Fei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes.
The well-known shortest path algorithm, Dijkstra’s algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network.
The genes occurring in any shortest path were considered as candidate AMD related genes.
As a result, 125 novel AMD genes were predicted.
The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability.
We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.
American Psychological Association (APA)
Zhang, Jian& Jiang, Min& Yuan, Fei& Feng, Kai-Yan& Cai, Yu-Dong& Xu, Xun…[et al.]. 2013. Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030622
Modern Language Association (MLA)
Zhang, Jian…[et al.]. Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030622
American Medical Association (AMA)
Zhang, Jian& Jiang, Min& Yuan, Fei& Feng, Kai-Yan& Cai, Yu-Dong& Xu, Xun…[et al.]. Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030622
