Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation
Joint Authors
Prado, Carla M.
Gobbato, Nathália Brandão
de Souza, Flávia Castro Ribas
Fumagalli, Stella Bruna Napolitano
Lopes, Fernanda Degobbi Tenório Quirino dos Santos
Leick, Edna Aparecida
Tibério, Iolanda F. L. C.
Martins, Milton Arruda
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Aims.
Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation.
Methods.
GP have inhaled ovalbumin (OVA group-2x/week/4weeks).
After the 4th inhalation, GP were treated with montelukast or dexamethasone.
After 72 hours of the 7th inhalation, GP were anesthetised, and lungs were removed and submitted to histopathological evaluation.
Results.
Montelukast and dexamethasone treatments reduced the number of eosinophils in airway wall and distal lung parenchyma compared to OVA group (P<0.05).
On distal parenchyma, both treatments were effective in reducing RANTES, NF-κB, and fibronectin positive cells compared to OVA group (P<0.001).
Montelukast was more effective in reducing eotaxin positive cells on distal parenchyma compared to dexamethasone treatment (P<0.001), while there was a more expressive reduction of IGF-I positive cells in OVA-D group (P<0.001).
On airway walls, montelukast and dexamethasone were effective in reducing IGF-I, RANTES, and fibronectin positive cells compared to OVA group (P<0.05).
Dexamethasone was more effective in reducing the number of eotaxin and NF-κB positive cells than Montelukast (P<0.05).
Conclusions.
In this animal model, both treatments were effective in modulating allergic inflammation and remodeling distal lung parenchyma and airway wall, contributing to a better control of the inflammatory response.
American Psychological Association (APA)
Gobbato, Nathália Brandão& de Souza, Flávia Castro Ribas& Fumagalli, Stella Bruna Napolitano& Lopes, Fernanda Degobbi Tenório Quirino dos Santos& Prado, Carla M.& Martins, Milton Arruda…[et al.]. 2013. Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1030623
Modern Language Association (MLA)
Gobbato, Nathália Brandão…[et al.]. Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1030623
American Medical Association (AMA)
Gobbato, Nathália Brandão& de Souza, Flávia Castro Ribas& Fumagalli, Stella Bruna Napolitano& Lopes, Fernanda Degobbi Tenório Quirino dos Santos& Prado, Carla M.& Martins, Milton Arruda…[et al.]. Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1030623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030623