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Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation
Joint Authors
Tanaka, Akane
Matsuda, Hiroshi
Amagai, Yosuke
Matsuda, Akira
Oida, Kumiko
Jung, Kyungsook
Nishikawa, Sho
Jang, Hyosun
Ishizaka, Saori
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Arthritis is a disabling health problem and commonly develops in the late stages of life; the condition is typically accompanied by chronic pain.
For the assessment of pain severity and therapeutic effects of analgesic drugs, we recently developed a gait analysis system, which provides an index of pain severity based on walking stride disturbance.
Using this system, we evaluated the therapeutic effect of topical nonsteroidal anti-inflammatory drugs (NSAIDs) in rat models of acute inflammation.
We found that the gait analysis system is more sensitive than conventional evaluation methods, such as measurement of swelling or analgesia, which indicated the superiority of our system for drug screening.
The approach also indicated that ketoprofen is superior to other NSAIDs for providing pain relief because of its higher skin permeability.
To the best of our knowledge, this is the first report demonstrating the effectiveness of topical NSAIDs in experimental animal models of acute inflammation.
American Psychological Association (APA)
Amagai, Yosuke& Tanaka, Akane& Matsuda, Akira& Oida, Kumiko& Jung, Kyungsook& Nishikawa, Sho…[et al.]. 2013. Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030644
Modern Language Association (MLA)
Amagai, Yosuke…[et al.]. Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030644
American Medical Association (AMA)
Amagai, Yosuke& Tanaka, Akane& Matsuda, Akira& Oida, Kumiko& Jung, Kyungsook& Nishikawa, Sho…[et al.]. Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030644