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Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System
Joint Authors
Modhia, Ishan
Mehta, Anant
Patel, Rupal
Patel, Chhaganbhai N.
Chavda, Hitesh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies.
Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively.
A 32 full factorial design was applied to optimize the concentration of chitosan and HPMC.
The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content, in vitro drug release, and stability studies.
To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models.
The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport.
The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.
American Psychological Association (APA)
Chavda, Hitesh& Modhia, Ishan& Mehta, Anant& Patel, Rupal& Patel, Chhaganbhai N.. 2013. Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030660
Modern Language Association (MLA)
Chavda, Hitesh…[et al.]. Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030660
American Medical Association (AMA)
Chavda, Hitesh& Modhia, Ishan& Mehta, Anant& Patel, Rupal& Patel, Chhaganbhai N.. Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030660