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Outcome of Prolonged Ventricular Fibrillation and CPR in a Rat Model of Chronic Ischemic Left Ventricular Dysfunction
Joint Authors
Sun, Shijie
Huang, Lei
Weil, Max Harry
Tang, Wanchun
Fang, Xiangshao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Patients with chronic left ventricular (LV) dysfunction are assumed to have a lower chance of successful CPR and lower likelihood of ultimate survival.
However, these assumptions have rarely been documented.
Therefore, we investigated the outcome of prolonged ventricular fibrillation (VF) and CPR in a rat model of chronic LV dysfunction.
Sprague-Dawley rats were randomized to (1) chronic LV dysfunction: animals underwent left coronary artery ligation; and (2) sham control.
Echocardiography was used to measure cardiac performance before surgery and 4 weeks after surgery.
Four weeks after surgical intervention, 8 min of VF was induced and defibrillation was delivered after 8 min of CPR.
LV dilation and low ejection fraction were observed 4 weeks after coronary ligation.
With optimal chest compressions, coronary perfusion pressure values during CPR were well maintained and indistinguishable between groups.
There were no differences in resuscitability and numbers of shock required for successful resuscitation between groups.
Despite the significantly decreased cardiac index in LV dysfunction animals before induction of VF, no differences in cardiac index were observed between groups following resuscitation, which was associated with the insignificant difference in postresuscitation survival.
In conclusion, the outcomes of CPR were not compromised by the preexisting chronic LV dysfunction.
American Psychological Association (APA)
Fang, Xiangshao& Huang, Lei& Sun, Shijie& Weil, Max Harry& Tang, Wanchun. 2013. Outcome of Prolonged Ventricular Fibrillation and CPR in a Rat Model of Chronic Ischemic Left Ventricular Dysfunction. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030663
Modern Language Association (MLA)
Fang, Xiangshao…[et al.]. Outcome of Prolonged Ventricular Fibrillation and CPR in a Rat Model of Chronic Ischemic Left Ventricular Dysfunction. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030663
American Medical Association (AMA)
Fang, Xiangshao& Huang, Lei& Sun, Shijie& Weil, Max Harry& Tang, Wanchun. Outcome of Prolonged Ventricular Fibrillation and CPR in a Rat Model of Chronic Ischemic Left Ventricular Dysfunction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030663