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Aqueous Extract of Annona macroprophyllata: A Potential α-Glucosidase Inhibitor
Joint Authors
Villalobos-Molina, R.
Brindis, F.
González-Trujano, M. E.
González-Andrade, M.
Aguirre-Hernández, E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Annona genus contains plants used in folk medicine for the treatment of diabetes.
In the present study, an aqueous extract prepared from Annona macroprophyllata (Annonaceae, also known as A.
diversifolia) leaves was evaluated on both the activity of yeast α-glucosidase (an in vitro assay) and sucrose tolerance in Wistar rats.
The results have shown that the aqueous extract from A.
macroprophyllata inhibits the yeast α-glucosidase with an IC50 = 1.18 mg/mL, in a competitive manner with a Ki = 0.97 mg/mL, a similar value to that of acarbose (Ki = 0.79 mg/mL).
The inhibitory activity of A.
macroprophyllata was reinforced by its antihyperglycemic effect, at doses of 100, 300, and 500 mg/kg in rats.
Chromatographic analysis identified the flavonoids rutin and isoquercitrin in the most polar fractions of A.
macroprophyllata crude extract, suggesting that these flavonoids are part of the active constituents in the plant.
Our results support the use of A.
macroprophyllata in Mexican folk medicine to control postprandial glycemia in people with diabetes mellitus, involving active constituents of flavonoid nature.
American Psychological Association (APA)
Brindis, F.& González-Trujano, M. E.& González-Andrade, M.& Aguirre-Hernández, E.& Villalobos-Molina, R.. 2013. Aqueous Extract of Annona macroprophyllata: A Potential α-Glucosidase Inhibitor. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030695
Modern Language Association (MLA)
Brindis, F.…[et al.]. Aqueous Extract of Annona macroprophyllata: A Potential α-Glucosidase Inhibitor. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030695
American Medical Association (AMA)
Brindis, F.& González-Trujano, M. E.& González-Andrade, M.& Aguirre-Hernández, E.& Villalobos-Molina, R.. Aqueous Extract of Annona macroprophyllata: A Potential α-Glucosidase Inhibitor. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030695