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Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma
Joint Authors
Metež Soldo, Kata
Salopek Rabatić, Jasminka
Tomić, Martina
Kaštelan, Snježana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Primary open-angle glaucoma (POAG), a chronic, degenerative optic neuropathy, requires persistent decrease of intraocular pressure so as to prevent visual impairment and blindness.
However, long-term use of topical ocular medications may affect ocular surface health.
Purpose of this study was to evaluate the influence of BAK-preserved prostaglandin analog treatment on the ocular surface health in patients with newly diagnosed POAG.
Methods.
40 newly diagnosed POAG patients were included in this prospective study.
Intraocular pressure (IOP), tear break-up time (TBUT), and ocular surface disease index (OSDI) were assessed at baseline and 3-month after starting treatment with BAK-preserved travoprost 0.004%.
Results.
IOP decreased in all patients from baseline to 3-month final visit (23.80 ± 1.73 mmHg versus 16.78 ± 1.27 mmHg; P<0.001).
Mean TBUT decreased from 11.70±1.86 seconds at baseline to 8.30 ± 1.29 seconds at 3-month final visit (<0.001).
Mean OSDI score increased from 31.63 ± 18.48 to 44.41 ± 16.48 (P<0.001).
Conclusions.
This study showed that BAK-preserved travoprost 0.004% is an effective medication in newly diagnosed POAG patients, but its long-term use may negatively influence ocular surface health by disrupting the tear film stability.
Further studies are needed to better understand the clinical effects of different preservative types and concentrations on the ocular surface.
American Psychological Association (APA)
Tomić, Martina& Kaštelan, Snježana& Metež Soldo, Kata& Salopek Rabatić, Jasminka. 2013. Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030703
Modern Language Association (MLA)
Tomić, Martina…[et al.]. Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030703
American Medical Association (AMA)
Tomić, Martina& Kaštelan, Snježana& Metež Soldo, Kata& Salopek Rabatić, Jasminka. Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030703