Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
Joint Authors
Escanero, Jesús F.
Borque, Luís
Urrechaga, Eloísa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Iron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores.
Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes.
The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction.
For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers.
Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost.
Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count.
Nevertheless these new parameters are exclusive of each manufacturer, and they are patented.
This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice.
American Psychological Association (APA)
Urrechaga, Eloísa& Borque, Luís& Escanero, Jesús F.. 2013. Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030704
Modern Language Association (MLA)
Urrechaga, Eloísa…[et al.]. Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030704
American Medical Association (AMA)
Urrechaga, Eloísa& Borque, Luís& Escanero, Jesús F.. Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030704