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Asthma Management in Sickle Cell Disease
Joint Authors
Gomez, Esteban
Morris, Claudia R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Asthma is a common comorbid factor in sickle cell disease (SCD).
However, the incidence of asthma in SCD is much higher than expected compared to rates in the general population.
Whether “asthma” in SCD is purely related to genetic and environmental factors or rather is the consequence of the underlying hemolytic and inflammatory state is a topic of recent debate.
Regardless of the etiology, hypoxemia induced by bronchoconstriction and inflammation associated with asthma exacerbations will contribute to a cycle of sickling and subsequent complications of SCD.
Recent studies confirm that asthma predisposes to complications of SCD such as pain crises, acute chest syndrome, and stroke and is associated with increased mortality.
Early recognition and aggressive standard of care management of asthma may prevent serious pulmonary complications and reduce mortality.
However, data regarding the management of asthma in SCD is very limited.
Clinical trials are needed to evaluate the effectiveness of current asthma therapy in patients with SCD and coincident asthma, while mechanistic studies are needed to delineate the underlying pathophysiology.
American Psychological Association (APA)
Gomez, Esteban& Morris, Claudia R.. 2013. Asthma Management in Sickle Cell Disease. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030705
Modern Language Association (MLA)
Gomez, Esteban& Morris, Claudia R.. Asthma Management in Sickle Cell Disease. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030705
American Medical Association (AMA)
Gomez, Esteban& Morris, Claudia R.. Asthma Management in Sickle Cell Disease. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030705