Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice
Joint Authors
Feder, David
Rodrigues Barros Godoy, Ivan
Guimarães Pereira, Maira Lazzarini
Silva, Cledson Silveira
Nogueira Silvestre, Diego
Alves de Siqueira Carvalho, Alzira
Aparecida dos Santos, Rosangela
Catteli Carvalho, Maria Helena
Fonseca, Fernando L. A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Several evidences show that muscles have an endocrine function.
Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles.
Methods.
The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains.
Results.
The mdx mice showed a significant increase in the steroid receptors mRNA when compared to the C57BL6 mice: levels of androgen(s) receptors in the heart, estrogen receptors alpha in the EDL, and estrogen receptors beta in the quadriceps were increased.
In addition, significant lowered levels of some other hormone receptors were found: corticosteroid receptors in the EDL and estrogen receptors alpha in the quadriceps.
Conclusion.
Dystrophic muscles bear significant differences in the expression of hormone receptors when compared to the C57BL6 mice strain.
The importance of such differences is yet to be better understood.
American Psychological Association (APA)
Feder, David& Rodrigues Barros Godoy, Ivan& Guimarães Pereira, Maira Lazzarini& Silva, Cledson Silveira& Nogueira Silvestre, Diego& Fonseca, Fernando L. A.…[et al.]. 2012. Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030707
Modern Language Association (MLA)
Feder, David…[et al.]. Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030707
American Medical Association (AMA)
Feder, David& Rodrigues Barros Godoy, Ivan& Guimarães Pereira, Maira Lazzarini& Silva, Cledson Silveira& Nogueira Silvestre, Diego& Fonseca, Fernando L. A.…[et al.]. Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030707