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Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum)
Joint Authors
Rahman, Heshu Sulaiman
Namvar, Farideh
Baharara, Javad
Zafar-Balanejad, Saeedeh
Fargahi, Fahimeh
Mohammad, Rosfarizan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the present study, we evaluated the effect of brown seaweeds Sargassum muticum methanolic extract (SMME), against MCF-7 and MDA-MB-231 breast cancer cell lines proliferation.
This algae extract was also evaluated for reducing activity and total polyphenol content.
The MTT assay results indicated that the extracts were cytotoxic against breast cancer cell lines in a dose-dependent manner, with IC50 of 22 μg/ml for MCF-7 and 55 μg/ml for MDA-MB-231 cell lines.
The percentages of apoptotic MCF-7-treated cells increased from 13% to 67% by increasing the concentration of the SMME.
The antiproliferative efficacy of this algal extract was positively correlated with the total polyphenol contents, suggesting a causal link related to extract content of phenolic acids.
Cell cycle analysis showed a significant increase in the accumulation of SMME-treated cells at sub-G1 phase, indicating the induction of apoptosis by SMME.
Further apoptosis induction was confirmed by Hoechst 33342 and AO/PI staining.
Also SMME implanted in vivo into fertilized chicken eggs induced dose-related antiangiogenic activity in the chorioallantoic membrane (CAM).
Our results imply a new insight on the novel function of Sargassum muticum polyphenol-rich seaweed in cancer research by induction of apoptosis, antioxidant, and antiangiogenesis effects.
American Psychological Association (APA)
Namvar, Farideh& Mohammad, Rosfarizan& Baharara, Javad& Zafar-Balanejad, Saeedeh& Fargahi, Fahimeh& Rahman, Heshu Sulaiman. 2013. Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum). BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030709
Modern Language Association (MLA)
Namvar, Farideh…[et al.]. Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum). BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030709
American Medical Association (AMA)
Namvar, Farideh& Mohammad, Rosfarizan& Baharara, Javad& Zafar-Balanejad, Saeedeh& Fargahi, Fahimeh& Rahman, Heshu Sulaiman. Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum). BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030709