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Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation
Joint Authors
Chen, Qishan
Zhang, Li
Xiao, Qingzhong
Zhu, Jianhua
Jin, Min
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Stem cells possess huge importance in developmental biology, disease modelling, cell replacement therapy, and tissue engineering in regenerative medicine because they have the remarkable potential for self-renewal and to differentiate into almost all the cell types in the human body.
Elucidation of molecular mechanisms regulating stem cell potency and differentiation is essential and critical for extensive application.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are modular proteins consisting of RNA-binding motifs and auxiliary domains characterized by extensive and divergent functions in nucleic acid metabolism.
Multiple roles of hnRNPs in transcriptional and posttranscriptional regulation enable them to be effective gene expression regulators.
More recent findings show that hnRNP proteins are crucial factors implicated in maintenance of stem cell self-renewal and pluripotency and cell differentiation.
The hnRNPs interact with certain sequences in target gene promoter regions to initiate transcription.
In addition, they recognize 3′UTR or 5′UTR of specific gene mRNA forming mRNP complex to regulate mRNA stability and translation.
Both of these regulatory pathways lead to modulation of gene expression that is associated with stem cell proliferation, cell cycle control, pluripotency, and committed differentiation.
American Psychological Association (APA)
Chen, Qishan& Jin, Min& Zhu, Jianhua& Xiao, Qingzhong& Zhang, Li. 2013. Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030726
Modern Language Association (MLA)
Chen, Qishan…[et al.]. Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030726
American Medical Association (AMA)
Chen, Qishan& Jin, Min& Zhu, Jianhua& Xiao, Qingzhong& Zhang, Li. Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030726