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Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions
Joint Authors
Mokhtari, Sepideh
Atarbashi Moghadam, Saede
Atarbashi Moghadam, Fazele
Eini, Ebrahim
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
P63 may have a role in tumorigenesis and cytodifferentiation of odontogenic lesions.
We investigated the immunohistochemical expression of P63 in a total of 30 cases of odontogenic cysts and tumors.
The percentage of positive cells was calculated in the lining of odontogenic cysts and islands of ameloblastoma.
P63 expression was evident in all types of odontogenic lesions.
P63 was expressed throughout the lining epithelium of odontogenic keratocyst except surface parakeratinized layer.
In addition, calcifying odontogenic cyst showed P63 expression in all layers.
In almost all radicular and dentigerous cysts, the basal and parabasal layers were immunoreactive.
Peripheral cells of ameloblastoma expressed P63; however, stellate reticulum had weaker immunostaining.
No significant difference in P63 expression was observed between studied lesions (P=0.86).
Expression of P63 in odontogenic lesions suggests that this protein is important in differentiation and proliferation of odontogenic epithelial cells.
However, it seems that it could not be a useful marker to differentiate between aggressive and nonaggressive lesions.
P63 also represents a progenitor or basal cell marker, and it is not expressed in mature differentiated cells.
American Psychological Association (APA)
Atarbashi Moghadam, Saede& Atarbashi Moghadam, Fazele& Mokhtari, Sepideh& Eini, Ebrahim. 2013. Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1030727
Modern Language Association (MLA)
Atarbashi Moghadam, Saede…[et al.]. Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1030727
American Medical Association (AMA)
Atarbashi Moghadam, Saede& Atarbashi Moghadam, Fazele& Mokhtari, Sepideh& Eini, Ebrahim. Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1030727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030727