Haplogroup T Is an Obesity Risk Factor: Mitochondrial DNA Haplotyping in a Morbid Obese Population from Southern Italy
Joint Authors
Sacchetti, Lucia
Nardelli, Carmela
Liguori, Rosario
Mazzaccara, Cristina
Ferrigno, Maddalena
Capobianco, Valentina
Pezzuti, Massimo
Farinaro, Eduardo
Contaldo, Franco
Buono, Pasqualina
Pasanisi, Fabrizio
Labruna, Giuseppe
Castaldo, Giuseppe
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Mitochondrial DNA (mtDNA) haplogroups have been associated with the expression of mitochondrial-related diseases and with metabolic alterations, but their role has not yet been investigated in morbid obese Caucasian subjects.
Therefore, we investigated the association between mitochondrial haplogroups and morbid obesity in patients from southern Italy.
The mtDNA D-loop of morbid obese patients (n=500; BMI > 40 kg/m2) and controls (n=216; BMI < 25 kg/m2) was sequenced to determine the mtDNA haplogroups.
The T and J haplogroup frequencies were higher and lower, respectively, in obese subjects than in controls.
Women bearing haplogroup T or J had twice or half the risk of obesity.
Binomial logistic regression analysis showed that haplogroup T and systolic blood pressure are risk factors for a high degree of morbid obesity, namely, BMI > 45 kg/m2 and in fact together account for 8% of the BMI.
In conclusion, our finding that haplogroup T increases the risk of obesity by about two-fold, suggests that, besides nuclear genome variations and environmental factors, the T haplogroup plays a role in morbid obesity in our study population from southern Italy.
American Psychological Association (APA)
Nardelli, Carmela& Labruna, Giuseppe& Liguori, Rosario& Mazzaccara, Cristina& Ferrigno, Maddalena& Capobianco, Valentina…[et al.]. 2013. Haplogroup T Is an Obesity Risk Factor: Mitochondrial DNA Haplotyping in a Morbid Obese Population from Southern Italy. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030743
Modern Language Association (MLA)
Nardelli, Carmela…[et al.]. Haplogroup T Is an Obesity Risk Factor: Mitochondrial DNA Haplotyping in a Morbid Obese Population from Southern Italy. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030743
American Medical Association (AMA)
Nardelli, Carmela& Labruna, Giuseppe& Liguori, Rosario& Mazzaccara, Cristina& Ferrigno, Maddalena& Capobianco, Valentina…[et al.]. Haplogroup T Is an Obesity Risk Factor: Mitochondrial DNA Haplotyping in a Morbid Obese Population from Southern Italy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030743