The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients
Joint Authors
Lin, Weili
Bunevicius, Adomas
Yuan, Hong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Extensive efforts have recently been devoted to developing noninvasive imaging tools capable of delineating brain tissue viability (penumbra) during acute ischemic stroke.
These efforts could have profound clinical implications for identifying patients who may benefit from tPA beyond the currently approved therapeutic time window and/or patients undergoing neuroendovascular treatments.
To date, the DWI/PWI MRI and perfusion CT have received the most attention for identifying ischemic penumbra.
However, their routine use in clinical settings remains limited.
Preclinical and clinical PET studies with [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) have consistently revealed a decreased 18F-FDG uptake in regions of presumed ischemic core.
More importantly, an elevated 18F-FDG uptake in the peri-ischemic regions has been reported, potentially reflecting viable tissues.
To this end, this paper provides a comprehensive review of the literature on the utilization of 14C-2-DG and 18F-FDG-PET in experimental as well as human stroke studies.
Possible cellular mechanisms and physiological underpinnings attributed to the reported temporal and spatial uptake patterns of 18F-FDG are addressed.
Given the wide availability of 18F-FDG in routine clinical settings, 18F-FDG PET may serve as an alternative, non-invasive tool to MRI and CT for the management of acute stroke patients.
American Psychological Association (APA)
Bunevicius, Adomas& Yuan, Hong& Lin, Weili. 2013. The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030745
Modern Language Association (MLA)
Bunevicius, Adomas…[et al.]. The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030745
American Medical Association (AMA)
Bunevicius, Adomas& Yuan, Hong& Lin, Weili. The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030745