Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks.
From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administered once in three weeks and telmisartan (5 mg/kg/day, p.o.) was administered daily.
4-NQO produced significant decrease in food intake, body weight, hyperglycemia, dyslipidemia, hypertension, and bradycardia, worsened hemodyanamics, increased cachexia markers like insulin, C-reactive protein, and interleukin-6, and increased tumor markers like lactate dehydrogenase and γ-glutamyl transferase.Treatment with combination of telmisartan with cisplatin produced significant increase in food intake and body weight and controlled hyperglycaemia and dyslipidemia, preserved hemodynamic function, and decreased the cachexia markers while cisplatin alone did not produce any increase in food intake and body weight.
Further, the combination of telmisartan with cisplatin significantly reduced tumor marker levels.
Combination of telmisartan with cisplatin prevented 4-NQO induced oxidative stress, hyperplasia and hyperkeratosis, premalignant dysplasia, and invasive squamous cell carcinoma in the tongue.
Our data suggests that combination of telmisartan with cisplatin treatment is beneficial in controlling cancer cachexia.
Telmisartan can be used as an add-on therapy with cisplatin or other traditional chemotherapeutic agents.
American Psychological Association (APA)
Patel, Bhoomika& Damle, Deepak. 2013. Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030759
Modern Language Association (MLA)
Patel, Bhoomika& Damle, Deepak. Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030759
American Medical Association (AMA)
Patel, Bhoomika& Damle, Deepak. Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030759