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Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation
Joint Authors
Durante, Alessandro
Agricola, Eustachio
Magri, Caroline J.
Chieffo, Alaide
Latib, Azeem
Montorfano, Matteo
Maisano, Francesco
Cioni, Michela
Covello, Remo Daniel
Gerli, Chiara
Franco, Annalisa
Spagnolo, Pietro
Alfieri, Ottavio
Colombo, Antonio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Vascular and bleeding complications remain important complications in patients undergoing percutaneous transfemoral transcatheter aortic valve implantation (TF-TAVI).
Platelets play an important role in bleeding events.
Mean platelet volume (MPV) is an indicator of platelet activation.
The objective of this study was to assess whether low MPV is an indicator of major vascular and bleeding complications following TF-TAVI.
Methods.
A retrospective cohort study of 330 subjects undergoing TF-TAVI implantation was performed.
The primary study endpoint was the occurrence of combined safety endpoint (CSEP); secondary endpoints included major vascular complications and life-threatening bleeding.
Endpoints were defined according to Valve Academic Research Consortium 2.
Results.
The CSEP at 30 days was reached in 30.9%; major vascular complications were observed in 14.9% while life-threatening bleeding occurred in 20.6%.
Logistic Euroscore and MPV were independent predictors of CSEP.
Predictors of vascular complications were female sex, previous myocardial infarction, red blood cell distribution width (RDW), and MPV while predictors of life-threatening bleeding were peripheral arterial disease, RDW, and MPV.
Conclusion.
A low baseline MPV was shown for the first time to be a significant predictor of CSEP, major vascular complications, and life-threatening bleeding following TF-TAVI.
American Psychological Association (APA)
Magri, Caroline J.& Chieffo, Alaide& Durante, Alessandro& Latib, Azeem& Montorfano, Matteo& Maisano, Francesco…[et al.]. 2013. Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030762
Modern Language Association (MLA)
Magri, Caroline J.…[et al.]. Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030762
American Medical Association (AMA)
Magri, Caroline J.& Chieffo, Alaide& Durante, Alessandro& Latib, Azeem& Montorfano, Matteo& Maisano, Francesco…[et al.]. Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030762