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Modification of Decellularized Goat-Lung Scaffold with ChitosanNanohydroxyapatite Composite for Bone Tissue Engineering Applications
Joint Authors
Gupta, Sweta K.
Dinda, Amit K.
Mishra, Narayan C.
Potdar, Pravin D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Decellularized goat-lung scaffold was fabricated by removing cells from cadaver goat-lung tissue, and the scaffold was modified with chitosan/nanohydroxyapatite composite for the purpose of bone tissue engineering applications.
MTT assay with osteoblasts, seeded over the chitosan/nanohydroxyapatite-modified decellularized scaffold, demonstrated significantly higher cell growth as compared to the decellularized scaffold without modification.
SEM analysis of cell-seeded scaffold, after incubation for 7 days, represented a good cell adhesion, and the cells spread over the chitosan/nanohydroxyapatite-modified decellularized scaffold.
Expression of bone-tissue-specific osteocalcin gene in the osteoblast cells grown over the chitosan/nanohydroxyapatite-modified decellularized scaffold clearly signifies that the cells maintained their osteoblastic phenotype with the chitosan/nanohydroxyapatite-modified decellularized scaffold.
Therefore, it can be concluded that the decellularized goat-lung scaffold-modified with chitosan/nanohydroxyapatite composite, may provide enhanced osteogenic potential when used as a scaffold for bone tissue engineering.
American Psychological Association (APA)
Gupta, Sweta K.& Dinda, Amit K.& Potdar, Pravin D.& Mishra, Narayan C.. 2013. Modification of Decellularized Goat-Lung Scaffold with ChitosanNanohydroxyapatite Composite for Bone Tissue Engineering Applications. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030765
Modern Language Association (MLA)
Gupta, Sweta K.…[et al.]. Modification of Decellularized Goat-Lung Scaffold with ChitosanNanohydroxyapatite Composite for Bone Tissue Engineering Applications. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030765
American Medical Association (AMA)
Gupta, Sweta K.& Dinda, Amit K.& Potdar, Pravin D.& Mishra, Narayan C.. Modification of Decellularized Goat-Lung Scaffold with ChitosanNanohydroxyapatite Composite for Bone Tissue Engineering Applications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030765