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Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis
Joint Authors
Mikroulis, Dimitrios
Bouros, Demosthenes
Tzouvelekis, Argyris
Ntolios, Paschalis
Vilaras, George
Boglou, Panagiotis
Archontogeorgis, Kostas
Kaltsas, Konstantinos
Sarikloglou, Evangelia
Steiropoulos, Paschalis
Koutsopoulos, Anastasios
Zacharis, George
Froudarakis, Marios
Karameris, Andreas
Koulelidis, Andreas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Emerging evidence supports the role of epidermal growth factor-receptor (EGFR) in fibrogenesis.
The aim of our study was to investigate the expression profiles of EGFR in three forms of IIPs, including idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), and nonspecific interstitial pneumonia (NSIP).
Patients and Methods.
Twenty newly diagnosed patients with IPF, 15 with COP, and 15 with NSIP (cellular, n=4 and fibrotic, n=11) were investigated.
Fifteen paraffin blocks obtained from the normal part of lungs removed for benign lesions were used as controls.
Immunohistochemistry was carried out using specific monoclonal antibody.
Results were verified by qRT-PCR.
Results.
A significant EGFR upregulation, both in protein and mRNA level, was observed in IPF, COP, and fibrotic NSIP samples compared to controls.
EGFR was primarily localized in the hyperplastic alveolar epithelium surrounding areas of fibrosis in IPF, COP, and fibrotic NSIP samples, as assessed by double immunohistochemistry analysis with surfactant protein-A.
EGFR mRNA levels were positively associated with indicators of lung fibrosis (type 1 collagen mRNA levels) and negatively correlated with functional prognostic parameters.
Conclusions.
We conclude that EGFR is upregulated in the hyperplastic alveolar epithelium in all three fibrotic forms of IIPs indicating a potential role during abnormal reepithelization.
American Psychological Association (APA)
Tzouvelekis, Argyris& Ntolios, Paschalis& Karameris, Andreas& Vilaras, George& Boglou, Panagiotis& Koulelidis, Andreas…[et al.]. 2013. Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030769
Modern Language Association (MLA)
Tzouvelekis, Argyris…[et al.]. Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030769
American Medical Association (AMA)
Tzouvelekis, Argyris& Ntolios, Paschalis& Karameris, Andreas& Vilaras, George& Boglou, Panagiotis& Koulelidis, Andreas…[et al.]. Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030769