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Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
Joint Authors
Lim, Michael
Zeng, Jing
Harris, Timothy J.
Drake, Charles G.
Tran, Phuoc T.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel.
Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model systems.
These studies demonstrate that radiation combined with immunotherapy can result in superior efficacy for local tumor control.
More alluring is the emergence of data suggesting an equally profound systemic response also known as “abscopal” effects with the combination of radiation and certain immunotherapies.
Studies addressing optimal radiation dose, fractionation, and modality to be used in combination with immunotherapy still require further exploration.
However, recent anecdotal clinical reports combining stereotactic or hypofractionated radiation regimens with immunotherapy have resulted in dramatic sustained clinical responses, both local and abscopal.
Technologic advances in clinical radiation therapy has made it possible to deliver hypofractionated regimens anywhere in the body using stereotactic radiation techniques, facilitating further clinical investigations.
Thus, stereotactic radiation in combination with immunotherapy agents represents an exciting and potentially fruitful new space for improving cancer therapeutic responses.
American Psychological Association (APA)
Zeng, Jing& Harris, Timothy J.& Lim, Michael& Drake, Charles G.& Tran, Phuoc T.. 2013. Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030770
Modern Language Association (MLA)
Zeng, Jing…[et al.]. Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030770
American Medical Association (AMA)
Zeng, Jing& Harris, Timothy J.& Lim, Michael& Drake, Charles G.& Tran, Phuoc T.. Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030770