Changes of Regulatory T and B Cells in Patients with Papillary Thyroid Carcinoma after 131I Radioablation: A Preliminary Study
Joint Authors
Jiang, Lei
Shi, Hongcheng
Gu, Yusen
Ye, Yi
Cheng, Yunfeng
Zhan, Yanxia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Lymphocytic infiltration and specific lymphocytes subsets may play important roles in papillary thyroid carcinoma (PTC) progression and prognosis.
In this study, we try to understand the influence of 131I radioablation on the important lymphocytes subtypes of regulatory T and B cells (Tregs and Bregs).
Methods.
Peripheral blood mononuclear cells from 30 PTC patients before and after 131I therapy, and 20 healthy donors were collected.
The expression of Tregs (CD4+CD25+CD127-/low) and B cell (CD5+CD19+) and production and secretion of interleukin 10 (IL-10) were analyzed by FACS and ELISA assay, respectively.
Results.
For Tregs percentage in peripheral blood lymphocytes, there was no difference between pretreatment and control and between posttreatment and control.
Compared with pretherapy, increased Tregs infiltration was noted in posttherapy (P<0.05).
Although no difference was between pretreatment and control, compared with these two groups, decreased CD19+ and CD5+CD19+ B cell percentage in posttreatment was observed (P<0.05).
Among these groups, no significant difference was displayed in intracellular IL-10 production and extracellular IL-10 secretion.
Conclusions.
131I Radioablation increased Tregs and decreased CD19+ and CD5+CD19+ B cells percentage after treatment.
However, it has no effect on IL-10 and lymphocytes in peripheral blood.
Therefore, longer follow-up of Tregs and Bregs should be further investigated.
American Psychological Association (APA)
Jiang, Lei& Zhan, Yanxia& Gu, Yusen& Ye, Yi& Cheng, Yunfeng& Shi, Hongcheng. 2013. Changes of Regulatory T and B Cells in Patients with Papillary Thyroid Carcinoma after 131I Radioablation: A Preliminary Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030785
Modern Language Association (MLA)
Jiang, Lei…[et al.]. Changes of Regulatory T and B Cells in Patients with Papillary Thyroid Carcinoma after 131I Radioablation: A Preliminary Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030785
American Medical Association (AMA)
Jiang, Lei& Zhan, Yanxia& Gu, Yusen& Ye, Yi& Cheng, Yunfeng& Shi, Hongcheng. Changes of Regulatory T and B Cells in Patients with Papillary Thyroid Carcinoma after 131I Radioablation: A Preliminary Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030785