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The Influence of Hemocoagulation Disorders on the Development of Posttraumatic Cerebral Infarction and Outcome in Patients with Moderate or Severe Head Trauma
Joint Authors
Xue, Li-Xia
Wang, Gan
Guo, Yan
Chen, Jiong
Cao, He-Li
Chen, Hao
Chen, Shi-Wen
Tian, Heng-Li
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Posttraumatic cerebral infarction (PTCI) is a severe secondary insult of head injury and often leads to a poor prognosis.
Hemocoagulation disorder is recognized to have important effects on hemorrhagic or ischemic damages.
We sought to assess if posttraumatic hemocoagulation disorders were associated with cerebral infarction, and evaluate their influence on outcome among patients with moderate or severe head trauma.
In this study, PTCI was observed in 28 (10.57%) of the 265 patients within the first week after injury.
In multivariate analysis, the thrombocytopenia (odds ratio (OR) 2.210, 95% confidence interval (CI) 1.065–4.674), abnormal prothrombin time (PT) (OR 3.241, 95% CI 1.090–7.648), D-dimer (>2 mg/L) (OR 7.260, 95% CI 1.822–28.076), or disseminated intravascular coagulation (DIC) scores (≥5) (OR 4.717, 95% CI 1.778–12.517) were each independently associated with an increased risk of PTCI.
Admission Glasgow Coma Scale (GCS) score, abnormal activated partial thromboplastin time (APTT) and fibrinogen, and D-dimer (>2 mg/L) and DIC scores (≥5) showed an independent predictive effect on poor outcome.
In conclusion, recognition of this important treatable cause of PTCI and the associated risk factors may help identify the group at risk and tailor management of patients with TBI.
American Psychological Association (APA)
Chen, Hao& Xue, Li-Xia& Guo, Yan& Cao, He-Li& Chen, Jiong& Tian, Heng-Li…[et al.]. 2013. The Influence of Hemocoagulation Disorders on the Development of Posttraumatic Cerebral Infarction and Outcome in Patients with Moderate or Severe Head Trauma. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030789
Modern Language Association (MLA)
Cao, He-Li…[et al.]. The Influence of Hemocoagulation Disorders on the Development of Posttraumatic Cerebral Infarction and Outcome in Patients with Moderate or Severe Head Trauma. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030789
American Medical Association (AMA)
Chen, Hao& Xue, Li-Xia& Guo, Yan& Cao, He-Li& Chen, Jiong& Tian, Heng-Li…[et al.]. The Influence of Hemocoagulation Disorders on the Development of Posttraumatic Cerebral Infarction and Outcome in Patients with Moderate or Severe Head Trauma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030789