Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor

Joint Authors

Marconi, Anna Maria
Virgili, Eleonora
Quadrelli, Federica
Doi, Patrizia
Samaja, Michele
Bulfamante, Gaetano Pietro
Garò, Chiara
Avagliano, Laura

Source

BioMed Research International

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-16

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Induction of labor is one of the most used procedures in obstetrics, performed to achieve vaginal delivery through cervical ripening and stimulation of uterine contractions.

We investigated the impact of induction of labor upon placental autophagy, a catabolic pathway activated in response to alteration of the physiological intracellular conditions.

We collected 28 singleton placentas at the time of uncomplicated term vaginal delivery (7 spontaneous onset of labor, 21 induced labor).

Autophagy was evaluated by immunohistochemistry, immunofluorescence, and immunoblotting.

No significant difference in the autophagy expression was found between spontaneous or induced onset of labor.

We found an inverse relationship between autophagy expression and the maternal prepregnancy body mass index, irrespective of the mode of labor onset.

This result could be related to the nutritional maternal habits before and throughout pregnancy rather than rapid metabolic changes during labor.

American Psychological Association (APA)

Avagliano, Laura& Virgili, Eleonora& Garò, Chiara& Quadrelli, Federica& Doi, Patrizia& Samaja, Michele…[et al.]. 2013. Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030794

Modern Language Association (MLA)

Avagliano, Laura…[et al.]. Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030794

American Medical Association (AMA)

Avagliano, Laura& Virgili, Eleonora& Garò, Chiara& Quadrelli, Federica& Doi, Patrizia& Samaja, Michele…[et al.]. Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030794

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1030794