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Microvesicles as Potential Ovarian Cancer Biomarkers
Joint Authors
Dolo, Vincenza
D’Ascenzo, Sandra
Giusti, Ilaria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic malignancy and typically has a poor prognosis.
To ensure optimal survival, it is important to diagnose this condition when the pathology is confined to the ovary.
However, this is difficult to achieve because the first specific symptoms appear only during advanced disease stages.
To date, the biomarker mainly used for the diagnosis and prognosis of ovarian cancer is CA125; however, this marker has a low sensitivity and specificity and is associated with several other physiological and pathological conditions.
No other serum ovarian cancer markers appear to be able to replace or complement CA125, and the current challenge is therefore to identify novel markers for the early diagnosis of this disease.
For this purpose, studies have focused on the microvesicles (MVs) released from tumor cells.
MVs may represent an ideal biomarker because they can be easily isolated from blood, and they have particular features (mainly regarding microRNA profiles) that strongly correlate with ovarian cancer stage and may be effective for early diagnosis.
American Psychological Association (APA)
Giusti, Ilaria& D’Ascenzo, Sandra& Dolo, Vincenza. 2013. Microvesicles as Potential Ovarian Cancer Biomarkers. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030813
Modern Language Association (MLA)
Giusti, Ilaria…[et al.]. Microvesicles as Potential Ovarian Cancer Biomarkers. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030813
American Medical Association (AMA)
Giusti, Ilaria& D’Ascenzo, Sandra& Dolo, Vincenza. Microvesicles as Potential Ovarian Cancer Biomarkers. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030813