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Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion
Joint Authors
al-Obaidi, Mazen M. Jamil
Soleimani Farjam, Abdoreza
Abdul Majid, Nazia
Gwaram, Nura Suleiman
Ali, Hapipah Mohd
Golbabapour, Shahram
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Schiff base complexes have appeared to be promising in the treatment of different diseases and disorders and have drawn a lot of attention to their biological activities.
This study was conducted to evaluate the regulatory effect of Schiff base metal derivatives on the expression of heat shock proteins (HSP) 70 and BAX in protection against acute haemorrhagic gastric ulcer in rats.
Rats were assigned to 6 groups of 6 rats: the normal control (Tween 20 5% v/v, 5 mL/kg), the positive control (Tween 20 5% v/v, 5 mL/kg), and four Schiff base derivative groups named Schiff_1, Schiff_2, Schiff_3, and Schiff_4 (25 mg/kg).
After 1 h, all of the groups received ethanol 95% (5 mL/kg) but the normal control received Tween 20 (Tween 20 5% v/v, 5 mL/kg).
The animals were euthanized after 60 min and the stomachs were dissected for histology (H&E), immunohistochemistry, and western blot analysis against HSP70 and BAX proteins.
The results showed that the Schiff base metal derivatives enhanced the expression of HSP70 and suppressed the expression of BAX proteins during their gastroprotection against ethanol-induced gastric lesion in rats.
American Psychological Association (APA)
Golbabapour, Shahram& Gwaram, Nura Suleiman& al-Obaidi, Mazen M. Jamil& Soleimani Farjam, Abdoreza& Ali, Hapipah Mohd& Abdul Majid, Nazia. 2013. Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030815
Modern Language Association (MLA)
Golbabapour, Shahram…[et al.]. Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030815
American Medical Association (AMA)
Golbabapour, Shahram& Gwaram, Nura Suleiman& al-Obaidi, Mazen M. Jamil& Soleimani Farjam, Abdoreza& Ali, Hapipah Mohd& Abdul Majid, Nazia. Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030815