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Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APPPS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
Joint Authors
Aliev, Gjumrakch
Li, Yi
Lombardi, Valter
Vigo, Carmen
Benberin, Valery V.
Cacabelos, Ramón
Palacios, Hector H.
Fernández-Novoa, Lucía
Etcheverría, Ignacio
Carrera, Iván
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
APP/PS1 double-transgenic mouse models of Alzheimer’s disease (AD), which overexpress mutated forms of the gene for human amyloid precursor protein (APP) and presenilin 1 (PS1), have provided robust neuropathological hallmarks of AD-like pattern at early ages.
This study characterizes immunocytochemical patterns of AD mouse brain as a model for human AD treated with the EB101 vaccine.
In this novel vaccine, a new approach has been taken to circumvent past failures by judiciously selecting an adjuvant consisting of a physiological matrix embedded in liposomes, composed of naturally occurring phospholipids (phosphatidylcholine, phosphatidylglycerol, and cholesterol).
Our findings showed that administration of amyloid-β1−42 (Aβ) and sphingosine-1-phosphate emulsified in liposome complex (EB101) to APP/PS1 mice before onset of Aβ deposition (7 weeks of age) and/or at an older age (35 weeks of age) is effective in halting the progression and clearing the AD-like neuropathological hallmarks.
Passive immunization with EB101 did not activate inflammatory responses from the immune system and astrocytes.
Consistent with a decreased inflammatory background, the basal immunological interaction between the T cells and the affected areas (hippocampus) in the brain of treated mice was notably reduced.
These results demonstrate that immunization with EB101 vaccine prevents and attenuates AD neuropathology in this type of double-transgenic mice.
American Psychological Association (APA)
Carrera, Iván& Etcheverría, Ignacio& Li, Yi& Fernández-Novoa, Lucía& Lombardi, Valter& Vigo, Carmen…[et al.]. 2013. Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APPPS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030823
Modern Language Association (MLA)
Carrera, Iván…[et al.]. Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APPPS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030823
American Medical Association (AMA)
Carrera, Iván& Etcheverría, Ignacio& Li, Yi& Fernández-Novoa, Lucía& Lombardi, Valter& Vigo, Carmen…[et al.]. Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APPPS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030823