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Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli
Joint Authors
Zhang, Wei
Li, Wei-na
Wang, Zeng-lu
Xue, Xiao-Chang
Yan, Zhen
Li, Meng
Qin, Xin
Zhang, Cun
Hao, Qiang
Zhao, Ning
Zhang, Ying-Qi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thymosin alpha 1 (Tα1), which is composed of 28 amino acids, has been commercialized worldwide for its immune-modulatory and antitumor effects.
Tα1 can stimulate T cell proliferation and differentiation from bone marrow stem cells, augment cell-mediated immune responses, and regulate homeostasis of immune system.
In this study, we developed a novel strategy to produce Tα1 concatemer (Tα1③) in Escherichia coli and compared its activity with chemically synthesized Tα1.
Results showed that Tα1③ can more effectively stimulate T cell proliferation and significantly upregulate IL-2 receptor expression.
We concluded that the expression system for Tα1 concatemer was constructed successfully, which could serve as an efficient tool for the production of large quantities of the active protein.
American Psychological Association (APA)
Xue, Xiao-Chang& Yan, Zhen& Li, Wei-na& Li, Meng& Qin, Xin& Zhang, Cun…[et al.]. 2013. Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030835
Modern Language Association (MLA)
Xue, Xiao-Chang…[et al.]. Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030835
American Medical Association (AMA)
Xue, Xiao-Chang& Yan, Zhen& Li, Wei-na& Li, Meng& Qin, Xin& Zhang, Cun…[et al.]. Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030835