CXCR1CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection
Joint Authors
Wei, Jing
Peng, Jing
Wang, Bing
Qu, Hong
Wang, Shiyi
Cheng, Jia-Wei
Gordon, John R.
Li, Fang
Aziz, Faisal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Klebsiella pneumoniae-associated pathology is largely mediated by neutrophilic inflammation.
In this study, we administered Klebsiella pneumoniae to experimental guinea pig groups and the ELR-CXC chemokine antagonist CXCL83–72, ceftazidime, and dexamethasone to different groups, respectively.
After 24 h, we assessed the animal’s pulmonary inflammatory levels, including gross histopathology, airway neutrophilia, lung myeloperoxidase levels, expressions of CXCL8 and TNF, and airway bacterial loads.
Compared with ceftazidime and dexamethasone treatments, the administration of the ELR-CXC chemokine antagonist CXCL83–72 alone was more effective than other methods, although it did not markedly attenuate the bacterial load.
These results suggest new methods for the treatment of Klebsiella pneumoniae pathology.
American Psychological Association (APA)
Wei, Jing& Peng, Jing& Wang, Bing& Qu, Hong& Wang, Shiyi& Aziz, Faisal…[et al.]. 2013. CXCR1CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030838
Modern Language Association (MLA)
Wei, Jing…[et al.]. CXCR1CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030838
American Medical Association (AMA)
Wei, Jing& Peng, Jing& Wang, Bing& Qu, Hong& Wang, Shiyi& Aziz, Faisal…[et al.]. CXCR1CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030838