Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin
Joint Authors
El-Sherbiny, Ibrahim M.
Guzman-Villanueva, Diana
Herrera-Ruiz, Dea
Smyth, Hugh D. C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties.
However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally.
In this study, curcumin was encapsulated in a series of novel nano-microparticulate systems developed to improve its aqueous solubility and stability.
The nano-microparticulate systems are based entirely on biocompatible, biodegradable, and edible polymers including chitosan, alginate, and carrageenan.
The particles were synthesized via ionotropic gelation.
Encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution compared to the free form of curcumin.
Also, the in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems after 9 hours in PBS at pH 7.4 when freeze-dried particles were used.
American Psychological Association (APA)
Guzman-Villanueva, Diana& El-Sherbiny, Ibrahim M.& Herrera-Ruiz, Dea& Smyth, Hugh D. C.. 2013. Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030845
Modern Language Association (MLA)
Guzman-Villanueva, Diana…[et al.]. Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030845
American Medical Association (AMA)
Guzman-Villanueva, Diana& El-Sherbiny, Ibrahim M.& Herrera-Ruiz, Dea& Smyth, Hugh D. C.. Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030845