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Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs
Joint Authors
Xu, Lei
Liu, Xin
Wu, Jingsheng
Zhu, Weibo
Cai, Xiaoyan
Sun, Zimin
Zhu, Xiao-Yu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The delivery of adipose-derived stem cells (ADSCs) for promoting tissue repair has become a potential new therapy, while hepatocyte growth factor (HGF) is an important growth factor with angiogenic, anti-fibrotic, and anti-inflammatory benefits.
In this paper, hADSCs were separated, cultured and identified based on the expression of cell surface antigens and multiple differentiation potential.
We successfully generated a lentiviral vector encoding human HGF, infected hADSCs with this vector and examined the protein expression pattern.
Finally we found that the hHGF lentiviral vector was successfully generated, and the lentiviral vector was able to safely infect hADSCs with high infection efficiency, thereby producing cells that overexpressed hHGF, which may provide a new strategy for the treatment of ischemic heart disease (IHD) and other ischemic diseases.
American Psychological Association (APA)
Zhu, Xiao-Yu& Xu, Lei& Liu, Xin& Wu, Jingsheng& Zhu, Weibo& Cai, Xiaoyan…[et al.]. 2013. Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030846
Modern Language Association (MLA)
Zhu, Xiao-Yu…[et al.]. Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030846
American Medical Association (AMA)
Zhu, Xiao-Yu& Xu, Lei& Liu, Xin& Wu, Jingsheng& Zhu, Weibo& Cai, Xiaoyan…[et al.]. Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030846