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Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model
Joint Authors
Lee, Sung Hak
Kang, Jung Won
Lin, Tao
Lee, Jae Eun
Jin, Dong-Il
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development.
Antiepileptic drugs (AEDs) arouse concern for the risk of teratogenicity, but the data are limited.
In this study, we evaluated the teratogenic potential of seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracetam (LVT), and topiramate (TPM)) in the zebrafish model.
Zebrafish embryos were exposed to AEDs from initiation of gastrula (5.25 hours post-fertilization (hpf)) to termination of hatching (72 hpf) which mimic the mammalian teratogenic experimental design.
The lethality and teratogenic index (TI) of AEDs were determined and the TI values of each drug were compared with the US FDA human pregnancy categories.
Zebrafish model was useful screening model for teratogenic potential of antiepilepsy drugs and was in concordance with in vivo mammalian data and human clinical data.
American Psychological Association (APA)
Lee, Sung Hak& Kang, Jung Won& Lin, Tao& Lee, Jae Eun& Jin, Dong-Il. 2013. Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030849
Modern Language Association (MLA)
Lee, Sung Hak…[et al.]. Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030849
American Medical Association (AMA)
Lee, Sung Hak& Kang, Jung Won& Lin, Tao& Lee, Jae Eun& Jin, Dong-Il. Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030849