Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent
Joint Authors
Norton, Harry James
Hanley, Edward N.
Mauerhan, David R.
Roberts, Andrea
Sun, Andrew R.
Sun, Yubo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Phosphocitrate (PC) inhibited meniscal calcification and the development of calcium crystal-associated osteoarthritis (OA) in Hartley guinea pigs.
However, the mechanisms remain elusive.
This study sought to examine the biological activities of PC in the absence of calcium crystals and test the hypothesis that PC is potentially a meniscal protective agent.
We found that PC downregulated the expression of many genes classified in cell proliferation, ossification, prostaglandin metabolic process, and wound healing, including bloom syndrome RecQ helicase-like, cell division cycle 7 homolog, cell division cycle 25 homolog C, ankylosis progressive homolog, prostaglandin-endoperoxide synthases-1/cyclooxygenase-1, and plasminogen activator urokinase receptor.
In contrast, PC stimulated the expression of many genes classified in fibroblast growth factor receptor signaling pathway, collagen fibril organization, and extracellular structure organization, including fibroblast growth factor 7, collagen type I, alpha 1, and collagen type XI, alpha 1.
Consistent with its effect on the expression of genes classified in cell proliferation, collagen fibril organization, and ossification, PC inhibited the proliferation of OA meniscal cells and meniscal cell-mediated calcification while stimulating the production of collagens.
These findings indicate that PC is potentially a meniscal-protective agent and a disease-modifying drug for arthritis associated with severe meniscal degeneration.
American Psychological Association (APA)
Sun, Yubo& Roberts, Andrea& Mauerhan, David R.& Sun, Andrew R.& Norton, Harry James& Hanley, Edward N.. 2013. Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030850
Modern Language Association (MLA)
Sun, Yubo…[et al.]. Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030850
American Medical Association (AMA)
Sun, Yubo& Roberts, Andrea& Mauerhan, David R.& Sun, Andrew R.& Norton, Harry James& Hanley, Edward N.. Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030850