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Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.
Joint Authors
Lim, Soon Sung
Kang, Young-Hee
Kim, Tae Hyeon
Lee, Jae-Yong
Kang, Il Jun
Kim, Jin Kyu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aldose reductase (AR) inhibitors have a considerable therapeutic potential against diabetes complications and do not increase the risk of hypoglycemia.
Through bioassay-guided fractionation of an EtOH extract of the kernel from purple corn (Zea mays L.), 7 nonanthocyanin phenolic compounds (compound 1–7) and 5 anthocyanins (compound 8–12) were isolated.
These compounds were investigated by rat lens aldose reductase (RLAR) inhibitory assays.
Kinetic analyses of recombinant human aldose reductase (rhAR) were performed, and intracellular galactitol levels were measured.
Hirsutrin, one of 12 isolated compounds, showed the most potent RLAR inhibitory activity (IC50, 4.78 μM).
In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/substrate concentration, hirsutrin showed competitive inhibition against rhAR.
Furthermore, hirsutrin inhibited galactitol formation in rat lens and erythrocytes sample incubated with a high concentration of galactose; this finding indicates that hirsutrin may effectively prevent osmotic stress in hyperglycemia.
Therefore, hirsutrin derived from Zea mays L.
may be a potential therapeutic agent against diabetes complications.
American Psychological Association (APA)
Kim, Tae Hyeon& Kim, Jin Kyu& Kang, Young-Hee& Lee, Jae-Yong& Kang, Il Jun& Lim, Soon Sung. 2013. Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030851
Modern Language Association (MLA)
Kim, Tae Hyeon…[et al.]. Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030851
American Medical Association (AMA)
Kim, Tae Hyeon& Kim, Jin Kyu& Kang, Young-Hee& Lee, Jae-Yong& Kang, Il Jun& Lim, Soon Sung. Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030851