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Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders
Joint Authors
Sapone, Anna
Siniscalco, Dario
de Magistris, Laura
Picardi, Annarita
Riccio, Maria Pia
Cariello, Rita
Abbadessa, Salvatore
Medici, Nicola
Lammers, Karen M.
Iardino, Patrizia
Tolone, Carlo
Pascotto, Antonio
Bravaccio, Carmela
Fasano, Alessio
Schiraldi, Chiara
Marotta, Rosa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Immune system of some autistic patients could be abnormally triggered by gluten/casein assumption.
The prevalence of antibodies to gliadin and milk proteins in autistic children with paired/impaired intestinal permeability and under dietary regimen either regular or restricted is reported.
Methods.
162 ASDs and 44 healthy children were investigated for intestinal permeability, tissue-transglutaminase (tTG), anti-endomysium antibodies (EMA)-IgA, and total mucosal IgA to exclude celiac disease; HLA-DQ2/-DQ8 haplotypes; total systemic antibodies (IgA, IgG, and IgE); specific systemic antibodies: α-gliadin (AGA-IgA and IgG), deamidated–gliadin-peptide (DGP-IgA and IgG), total specific gliadin IgG (all fractions: α, β, γ, and ω), β-lactoglobulin IgG, α-lactalbumin IgG, casein IgG; and milk IgE, casein IgE, gluten IgE, -lactoglobulin IgE, and α-lactalbumin IgE.
Results.
AGA-IgG and DPG-IgG titers resulted to be higher in ASDs compared to controls and are only partially influenced by diet regimen.
Casein IgG titers resulted to be more frequently and significantly higher in ASDs than in controls.
Intestinal permeability was increased in 25.6% of ASDs compared to 2.3% of healthy children.
Systemic antibodies production was not influenced by paired/impaired intestinal permeability.
Conclusions.
Immune system of a subgroup of ASDs is triggered by gluten and casein; this could be related either to AGA, DPG, and Casein IgG elevated production or to impaired intestinal barrier function.
American Psychological Association (APA)
de Magistris, Laura& Picardi, Annarita& Siniscalco, Dario& Riccio, Maria Pia& Sapone, Anna& Cariello, Rita…[et al.]. 2013. Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030853
Modern Language Association (MLA)
de Magistris, Laura…[et al.]. Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030853
American Medical Association (AMA)
de Magistris, Laura& Picardi, Annarita& Siniscalco, Dario& Riccio, Maria Pia& Sapone, Anna& Cariello, Rita…[et al.]. Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030853