Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity
Joint Authors
Molina-Jijón, Eduardo
Rodríguez-Muñoz, Rafael
Bautista-García, Pablo
Debray-García, Yazmin
Namorado, María del Carmen
Reyes, José L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Kidney is a target organ for heavy metals.
They accumulate in several segments of the nephron and cause profound alterations in morphology and function.
Acute intoxication frequently causes acute renal failure.
The effects of chronic exposure have not been fully disclosed.
In recent years increasing awareness of the consequences of their presence in the kidney has evolved.
In this review we focus on the alterations induced by heavy metals on the intercellular junctions of the kidney.
We describe that in addition to the proximal tubule, which has been recognized as the main site of accumulation and injury, other segments of the nephron, such as glomeruli, vessels, and distal nephron, show also deleterious effects.
We also emphasize the participation of oxidative stress as a relevant component of the renal damage induced by heavy metals and the beneficial effect that some antioxidant drugs, such as vitamin A (all-trans-retinoic acid) and vitamin E (α-tocopherol), depict on the morphological and functional alterations induced by heavy metals.
American Psychological Association (APA)
Reyes, José L.& Molina-Jijón, Eduardo& Rodríguez-Muñoz, Rafael& Bautista-García, Pablo& Debray-García, Yazmin& Namorado, María del Carmen. 2013. Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030855
Modern Language Association (MLA)
Reyes, José L.…[et al.]. Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030855
American Medical Association (AMA)
Reyes, José L.& Molina-Jijón, Eduardo& Rodríguez-Muñoz, Rafael& Bautista-García, Pablo& Debray-García, Yazmin& Namorado, María del Carmen. Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030855