Expression Analysis of SPARCOsteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
Joint Authors
Aversa, C.
Losito, Simona
Aquino, Gabriella
Sabatino, Rocco
Cantile, Monica
Botti, Gerardo
La Mantia, Elvira
Collina, Francesca
Malzone, Gabriella
Pannone, Giuseppe
Ionna, F.
Franco, Renato
Longo, F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide.
The molecular mechanisms related to the pathogenesis of this disease are still poorly understood.
The discovery of a molecular marker that allows the early detection of this cancer, which can be easily identified in biological samples, such as saliva, without intervening in advanced stages, is a challenge.
Numerous studies have identified a panel of molecular markers differently expressed in OSCC and normal oral mucosa.
In particular, it was found an aberrant expression of matricellular glycoprotein SPARC.
SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation.
In fact, aberrant SPARC expression was detected both in stromal cells associated with cancer and in tumor cells.
The aim of our study was the evaluation of SPARC on a retrospective series of 119 OSCC cases and the validation of the obtained data on a prospective series of 27 patients with OSCC, of whom we have previously collected saliva, and smeared material.
The obtained results were correlated with each other and with clinical pathological parameters at our disposal.
The study demonstrated a prognostic value of SPARC, especially with regard to its expression in the stroma surrounding OSCC (P < 0.05).
American Psychological Association (APA)
Aquino, Gabriella& Sabatino, Rocco& Cantile, Monica& Aversa, C.& Ionna, F.& Botti, Gerardo…[et al.]. 2013. Expression Analysis of SPARCOsteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030859
Modern Language Association (MLA)
Aquino, Gabriella…[et al.]. Expression Analysis of SPARCOsteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030859
American Medical Association (AMA)
Aquino, Gabriella& Sabatino, Rocco& Cantile, Monica& Aversa, C.& Ionna, F.& Botti, Gerardo…[et al.]. Expression Analysis of SPARCOsteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030859