Coefficient of Energy Balance: Effective Tool for Early Differential Diagnosis of CNS Diseases
Joint Authors
Sobek, Ondřej
Hajduková, Lenka
Lánská, Věra
Nekola, Petr
Bořecká, Klára
Adam, Pavel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Urgent examination of cerebrospinal fluid (CSF) provides immediate important information about the character of central nervous system (CNS) impairment.
Although this examination includes energy parameters such as glucose and lactate concentrations, it does not commonly use Coefficient of Energy Balance (CEB).
In this study, we focused on CEB because it enables more exact assessment of actual energy state in the CSF compartment than glucose and lactate alone.
CEB informs about the actual functioning condition of present cells, and it does not require any other analysis or costs.
Using Kruskal-Wallis ANOVA, we examined a large CSF sample (n=8183) and we compared CEB values among groups with different cytological syndromes.
We found a statistically significant difference of CEB between the group with granulocyte pleocytosis and the control group.
These results indicate a high degree of anaerobic metabolism caused by the oxidative burst of neutrophils.
Similarly, we found a statistically significant difference of CEB between the control group and groups with tumorous oligocytosis plus pleocytosis and monocyte pleocytosis.
This difference can be attributed to the oxidative burst of macrophages.
Our findings suggest that CEB combined with CSF cytology has a great importance for diagnosis, differential diagnosis, and early therapy of CNS diseases.
American Psychological Association (APA)
Bořecká, Klára& Adam, Pavel& Sobek, Ondřej& Hajduková, Lenka& Lánská, Věra& Nekola, Petr. 2013. Coefficient of Energy Balance: Effective Tool for Early Differential Diagnosis of CNS Diseases. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030870
Modern Language Association (MLA)
Bořecká, Klára…[et al.]. Coefficient of Energy Balance: Effective Tool for Early Differential Diagnosis of CNS Diseases. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030870
American Medical Association (AMA)
Bořecká, Klára& Adam, Pavel& Sobek, Ondřej& Hajduková, Lenka& Lánská, Věra& Nekola, Petr. Coefficient of Energy Balance: Effective Tool for Early Differential Diagnosis of CNS Diseases. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030870