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Prescription Surveillance and Polymerase Chain Reaction Testing to Identify Pathogens during Outbreaks of Infection
Joint Authors
Sugiura, Hiroaki
Sugawara, Tamie
Konagaya, Masami
Kikuchi, Kiyoshi
Hanada, Eisuke
Okabe, Nobuhiko
Ohkusa, Yasushi
Hanaoka, Nozomu
Fujimoto, Tsuguto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Syndromic surveillance, including prescription surveillance, offers a rapid method for the early detection of agents of bioterrorism and emerging infectious diseases.
However, it has the disadvantage of not considering definitive diagnoses.
Here, we attempted to definitively diagnose pathogens using polymerase chain reaction (PCR) immediately after the prescription surveillance system detected an outbreak.
Specimens were collected from 50 patients with respiratory infections.
PCR was used to identify the pathogens, which included 14 types of common respiratory viruses and Mycoplasma pneumoniae.
Infectious agents including M.
pneumoniae, respiratory syncytial virus (RSV), rhinovirus, enterovirus, and parainfluenza virus were detected in 54% of patients.
For the rapid RSV diagnosis kit, sensitivity was 80% and specificity was 85%.
For the rapid adenovirus diagnosis kit, no positive results were obtained; therefore, sensitivity could not be calculated and specificity was 100%.
Many patients were found to be treated for upper respiratory tract infections without the diagnosis of a specific pathogen.
In Japan, an outbreak of M.
pneumoniae infection began in 2011, and our results suggested that this outbreak may have included false-positive cases.
By combining syndromic surveillance and PCR, we were able to rapidly and accurately identify causative pathogens during a recent respiratory infection outbreak.
American Psychological Association (APA)
Sugiura, Hiroaki& Fujimoto, Tsuguto& Sugawara, Tamie& Hanaoka, Nozomu& Konagaya, Masami& Kikuchi, Kiyoshi…[et al.]. 2013. Prescription Surveillance and Polymerase Chain Reaction Testing to Identify Pathogens during Outbreaks of Infection. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030871
Modern Language Association (MLA)
Sugiura, Hiroaki…[et al.]. Prescription Surveillance and Polymerase Chain Reaction Testing to Identify Pathogens during Outbreaks of Infection. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030871
American Medical Association (AMA)
Sugiura, Hiroaki& Fujimoto, Tsuguto& Sugawara, Tamie& Hanaoka, Nozomu& Konagaya, Masami& Kikuchi, Kiyoshi…[et al.]. Prescription Surveillance and Polymerase Chain Reaction Testing to Identify Pathogens during Outbreaks of Infection. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030871