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Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes
Joint Authors
Zhao, Ping
Yang, Xiaoyang
Qi, Shibo
Hoppmann, Susan
Cao, Qizhen
Chua, Mei-Sze
So, Samuel K.
Cheng, Zhen
Jiang, Han
Liu, Hongguang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a highly aggressive and lethal cancer.
It is typically asymptomatic at the early stage, with only 10%–20% of HCC patients being diagnosed early enough for appropriate surgical treatment.
The delayed diagnosis of HCC is associated with limited treatment options and much lower survival rates.
Therefore, the early and accurate detection of HCC is crucial to improve its currently dismal prognosis.
The epidermal growth factor receptor (EGFR) has been reported to be involved in HCC tumorigenesis and to represent an attractive target for HCC imaging and therapy.
In this study, an affibody molecule, Ac-Cys-ZEGFR:1907, targeting the extracellular domain of EGFR, was used for the first time to assess its potential to detect HCC xenografts.
By evaluating radio- or fluorescent-labeled Ac-Cys-ZEGFR:1907 as a probe for positron emission tomography (PET) or optical imaging of HCC, subcutaneous EGFR-positive HCC xenografts were found to be successfully imaged by the PET probe.
Thus, affibody-based PET imaging of EGFR provides a promising approach for detecting HCC in vivo.
American Psychological Association (APA)
Zhao, Ping& Yang, Xiaoyang& Qi, Shibo& Liu, Hongguang& Jiang, Han& Hoppmann, Susan…[et al.]. 2013. Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030884
Modern Language Association (MLA)
Zhao, Ping…[et al.]. Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030884
American Medical Association (AMA)
Zhao, Ping& Yang, Xiaoyang& Qi, Shibo& Liu, Hongguang& Jiang, Han& Hoppmann, Susan…[et al.]. Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030884