The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis
Joint Authors
Caporali, Roberto
Boffini, Nicola
Grosso, Vittorio
Monti, Sara
Scorletti, Eva
Crepaldi, Gloria
Cavagna, Lorenzo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Interstitial lung disease (ILD) is a relevant extra-articular manifestation of rheumatoid arthritis (RA) that may occur either in early stages or as a complication of long-standing disease.
RA related ILD (RA-ILD) significantly influences the quoad vitam prognosis of these patients.
Several histopathological patterns of RA-ILD have been described: usual interstitial pneumonia (UIP) is the most frequent one, followed by nonspecific interstitial pneumonia (NSIP); other patterns are less commonly observed.
Several factors have been associated with an increased risk of developing RA-ILD.
The genetic background plays a fundamental but not sufficient role; smoking is an independent predictor of ILD, and a correlation with the presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies has also been reported.
Moreover, both exnovo occurrence and progression of ILD have been related to drug therapies that are commonly prescribed in RA, such as methotrexate, leflunomide, anti-TNF alpha agents, and rituximab.
A greater understanding of the disease process is necessary in order to improve the therapeutic approach to ILD and RA itself and to reduce the burden of this severe extra-articular manifestation.
American Psychological Association (APA)
Cavagna, Lorenzo& Monti, Sara& Grosso, Vittorio& Boffini, Nicola& Scorletti, Eva& Crepaldi, Gloria…[et al.]. 2013. The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030886
Modern Language Association (MLA)
Cavagna, Lorenzo…[et al.]. The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030886
American Medical Association (AMA)
Cavagna, Lorenzo& Monti, Sara& Grosso, Vittorio& Boffini, Nicola& Scorletti, Eva& Crepaldi, Gloria…[et al.]. The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030886