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Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species
Joint Authors
Chanvorachote, Pithi
Kowitdamrong, Akkarawut
Sritularak, Boonchoo
Pongrakhananon, Varisa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is the leading cause of death among cancer patients worldwide, and most of them have died from metastasis.
Migration and invasion are prerequisite processes associated with high metastasis potential in cancers.
Moscatilin, a bibenzyl derivative isolated from the Thai orchid Dendrobium pulchellum, has been shown to have anticancer effect against numerous cancer cell lines.
However, little is known regarding the effect of moscatilin on cancer cell migration and invasion.
The present study demonstrates that nontoxic concentrations of moscatilin were able to inhibit human nonsmall cell lung cancer H23 cell migration and invasion.
The inhibitory effect of moscatilin was associated with an attenuation of endogenous reactive oxygen species (ROS), in which hydroxyl radical (OH∙) was identified as a dominant species in the suppression of filopodia formation.
Western blot analysis also revealed that moscatilin downregulated activated focal adhesion kinase (phosphorylated FAK, Tyr 397) and activated ATP-dependent tyrosine kinase (phosphorylated Akt, Ser 473), whereas their parental counterparts were not detectable changed.
In conclusion, our results indicate the novel molecular basis of moscalitin-inhibiting lung cancer cell motility and invasion and demonstrate a promising antimetastatic potential of such an agent for lung cancer therapy.
American Psychological Association (APA)
Kowitdamrong, Akkarawut& Chanvorachote, Pithi& Sritularak, Boonchoo& Pongrakhananon, Varisa. 2013. Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030894
Modern Language Association (MLA)
Kowitdamrong, Akkarawut…[et al.]. Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030894
American Medical Association (AMA)
Kowitdamrong, Akkarawut& Chanvorachote, Pithi& Sritularak, Boonchoo& Pongrakhananon, Varisa. Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030894