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A Partial Volume Effect Correction Tailored for 18F-FDG-PET Oncological Studies
Joint Authors
Salvatore, Christian
Gallivanone, F.
Canevari, C.
Gianolli, L.
Della Rosa, P. A.
Castiglioni, I.
Gilardi, Maria Carla
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We have developed, optimized, and validated a method for partial volume effect (PVE) correction of oncological lesions in positron emission tomography (PET) clinical studies, based on recovery coefficients (RC) and on PET measurements of lesion-to-background ratio (L/Bm) and of lesion metabolic volume.
An operator-independent technique, based on an optimised threshold of the maximum lesion uptake, allows to define an isocontour around the lesion on PET images in order to measure both lesion radioactivity uptake and lesion metabolic volume.
RC are experimentally derived from PET measurements of hot spheres in hot background, miming oncological lesions.
RC were obtained as a function of PET measured sphere-to-background ratio and PET measured sphere metabolic volume, both resulting from the threshold-isocontour technique.
PVE correction of lesions of a diameter ranging from 10 mm to 40 mm and for measured L/Bm from 2 to 30 was performed using measured RC curves tailored at answering the need to quantify a large variety of real oncological lesions by means of PET.
Validation of the PVE correction method resulted to be accurate (>89%) in clinical realistic conditions for lesion diameter > 1 cm, recovering >76% of radioactivity for lesion diameter < 1 cm.
Results from patient studies showed that the proposed PVE correction method is suitable and feasible and has an impact on a clinical environment.
American Psychological Association (APA)
Gallivanone, F.& Canevari, C.& Gianolli, L.& Salvatore, Christian& Della Rosa, P. A.& Gilardi, Maria Carla…[et al.]. 2013. A Partial Volume Effect Correction Tailored for 18F-FDG-PET Oncological Studies. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030902
Modern Language Association (MLA)
Gallivanone, F.…[et al.]. A Partial Volume Effect Correction Tailored for 18F-FDG-PET Oncological Studies. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030902
American Medical Association (AMA)
Gallivanone, F.& Canevari, C.& Gianolli, L.& Salvatore, Christian& Della Rosa, P. A.& Gilardi, Maria Carla…[et al.]. A Partial Volume Effect Correction Tailored for 18F-FDG-PET Oncological Studies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030902