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Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy
Joint Authors
Lee, Jong-Min
Yoon, Tae-Jong
Cho, Young-Seok
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that enables sequence-specific gene silencing by promoting degradation of specific mRNAs.
Molecular therapy using small interfering RNA (siRNA) has shown great therapeutic potential for diseases caused by abnormal gene overexpression or mutation.
The major challenges to application of siRNA therapeutics include the stability and effective delivery of siRNA in vivo.
Important progress in nanotechnology has led to the development of efficient siRNA delivery systems.
In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy.
This review will also offer perspectives on future applications of siRNA therapeutics.
American Psychological Association (APA)
Lee, Jong-Min& Yoon, Tae-Jong& Cho, Young-Seok. 2013. Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030903
Modern Language Association (MLA)
Lee, Jong-Min…[et al.]. Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030903
American Medical Association (AMA)
Lee, Jong-Min& Yoon, Tae-Jong& Cho, Young-Seok. Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030903