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Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid
Joint Authors
Radhakrishnan, Ammu
Mahalingam, Dashayini
Selvaduray, Kanga Rani
Nesaretnam, Kalanithi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study compared the ability of three forms of vitamin E [tocotrienol-rich fraction (TRF), alpha-tocopherol (α-T), and delta-tocotrienol (δ-T3)] to enhance immune response to tetanus toxoid (TT) immunisation in a mouse model.
Twenty BALB/c mice were divided into four groups of five mice each.
The mice were fed with the different forms of vitamin E (1 mg) or vehicle daily for two weeks before they were given the TT vaccine [4 Lf] intramuscularly (i.m.).
Booster vaccinations were given on days 28 and 42.
Serum was collected (days 0, 28, and 56) to quantify anti-TT levels.
At autopsy, splenocytes harvested were cultured with TT or mitogens.
The production of anti-TT antibodies was augmented (P<0.05) in mice that were fed with δ-T3 or TRF compared to controls.
The production of IFN-γ and IL-4 by splenocytes from the vitamin E treated mice was significantly (P<0.05) higher than that from controls.
The IFN-γ production was the highest in animals supplemented with δ-T3 followed by TRF and finally α-T.
Production of TNF-α was suppressed in the vitamin E treated group compared to vehicle-supplemented controls.
Supplementation with δ-T3 or TRF can enhance immune response to TT immunisation and production of cytokines that promote cell-mediated (TH1) immune response.
American Psychological Association (APA)
Radhakrishnan, Ammu& Mahalingam, Dashayini& Selvaduray, Kanga Rani& Nesaretnam, Kalanithi. 2013. Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030904
Modern Language Association (MLA)
Radhakrishnan, Ammu…[et al.]. Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030904
American Medical Association (AMA)
Radhakrishnan, Ammu& Mahalingam, Dashayini& Selvaduray, Kanga Rani& Nesaretnam, Kalanithi. Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030904