The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats
Joint Authors
Li, Wan-Shu
Liu, Xian-yun
Xu, Tao
Luo, Jun
Geng, Pei-wu
Wang, Li
Xia, Meng-ming
Yu, Lei
Hu, Guo-xin
Chen, Mengchun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study was to determine the effect of apigenin on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats.
Healthy male SD rats were randomly divided into four groups: A group (the control group), B group (the long-term administration of 165 mg/kg apigenin for 15 days), C group (a single dose of 165 mg/kg apigenin), and D group (a single dose of 252 mg/kg apigenin).
The serum concentrations of imatinib and N-desmethyl imatinib were measured by HPLC, and pharmacokinetic parameters were calculated using DAS 3.0 software.
The parameters of AUC(0-t), AUC(0−∞), Tmax, Vz/F, and CLz/F for imatinib in group B were different from those in group A (P<0.05).
Besides, MRT(0−t) and MRT(0−∞) in groups C and D differed distinctly from those in group A as well.
The parameters of AUC(0-t) and Cmax for N-desmethyl imatinib in group C were significantly lower than those in group A (P<0.05); however, compared with groups B and D, the magnitude of effect was modest.
Those results indicated that apigenin in the short-term study inhibited the metabolism of imatinib and its metabolite N-desmethyl imatinib, while in the long-term study the metabolism could be accelerated.
American Psychological Association (APA)
Liu, Xian-yun& Xu, Tao& Li, Wan-Shu& Luo, Jun& Geng, Pei-wu& Wang, Li…[et al.]. 2013. The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030913
Modern Language Association (MLA)
Liu, Xian-yun…[et al.]. The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030913
American Medical Association (AMA)
Liu, Xian-yun& Xu, Tao& Li, Wan-Shu& Luo, Jun& Geng, Pei-wu& Wang, Li…[et al.]. The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030913