Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol
Joint Authors
Kuchekar, Bhanudas S.
Bari, Nilesh A.
Jagdale, Swati C.
Chabukswar, Aniruddha R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol.
Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release.
The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent.
The rapid release core tablet (RRCT) was prepared by using superdisintegrants with active ingredient.
Press coating of optimized RRCT was done by polymer.
A 32 full factorial design was used for optimization.
The amount of Polyox WSR205 and Polyox WSR N12K was selected as independent variables.
Lag period, drug release, and swelling index were selected as dependent variables.
Floating pulsatile release formulation (FPRT) F13 at level 0 (55 mg) for Polyox WSR205 and level +1 (65 mg) for Polyox WSR N12K showed lag time of 4 h with >90% drug release.
The data were statistically analyzed using ANOVA, and P<0.05 was statistically significant.
Release kinetics of the optimized formulation best fitted the zero order model.
In vivo study confirms burst effect at 4 h in indicating the optimization of the dosage form.
American Psychological Association (APA)
Jagdale, Swati C.& Bari, Nilesh A.& Kuchekar, Bhanudas S.& Chabukswar, Aniruddha R.. 2013. Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030934
Modern Language Association (MLA)
Jagdale, Swati C.…[et al.]. Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030934
American Medical Association (AMA)
Jagdale, Swati C.& Bari, Nilesh A.& Kuchekar, Bhanudas S.& Chabukswar, Aniruddha R.. Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030934