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Parthenium hysterophorus: A Probable Source of Anticancer, Antioxidant and Anti-HIV Agents
Joint Authors
Kumar, Shashank
Chashoo, Gousia
Saxena, Ajit K.
Pandey, Abhay K.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P.
hysterophorus leaf.
Dried leaf samples were sequentially extracted with nonpolar and polar solvents.
Ethanol fraction showed noticeable cytotoxic activity (81–85%) in SRB assay against MCF-7 and THP-1 cancer cell lines at 100 μg/ml concentration, while lower activity was observed with DU-145 cell line.
The same extract exhibited 17–98% growth inhibition of HL-60 cancer cell lines in MTT assay, showing concentration dependent response.
Ethanol extract caused 12% reduction in mitochondrial membrane potential and 10% increment in sub G1 population of HL-60 cell lines.
Several leaf fractions, namely, ethyl acetate, ethanol, and aqueous fractions exhibited considerable reducing capability at higher concentrations.
Most of the extracts demonstrated appreciable (>75%) metal ion chelating and hydroxyl radical scavenging activities at 200 µg/ml.
All the extracts except aqueous fraction accounted for about 70–80% inhibition of lipid peroxidation in rat liver homogenate indicating protective response against membrane damage.
About 40% inhibition of reverse transcriptase (RT) activity was observed in hexane fraction in anti-HIV assay at 6.0 µg/ml concentration.
The study showed that phytochemicals present in P.
hysterophorus leaf have considerable potential as cytotoxic and antioxidant agents with low to moderate anti-HIV activity.
American Psychological Association (APA)
Kumar, Shashank& Chashoo, Gousia& Saxena, Ajit K.& Pandey, Abhay K.. 2013. Parthenium hysterophorus: A Probable Source of Anticancer, Antioxidant and Anti-HIV Agents. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030947
Modern Language Association (MLA)
Kumar, Shashank…[et al.]. Parthenium hysterophorus: A Probable Source of Anticancer, Antioxidant and Anti-HIV Agents. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030947
American Medical Association (AMA)
Kumar, Shashank& Chashoo, Gousia& Saxena, Ajit K.& Pandey, Abhay K.. Parthenium hysterophorus: A Probable Source of Anticancer, Antioxidant and Anti-HIV Agents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030947