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Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging
Joint Authors
Li, Kefeng
Bai, Rongjie
Jiang, Huijie
Hao, Xuejia
Ling, Zaisheng
Ma, Guo-Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rationale and Objectives.
To develop an optimal scanning protocol for multislice spiral CT perfusion (CTP) imaging to evaluate hemodynamic changes in liver cirrhosis with diethylnitrosamine- (DEN-) induced precancerous lesions.
Materials and Methods.
Male Wistar rats were randomly divided into the control group (n=80) and the precancerous liver cirrhosis group (n=40).
The control group received saline injection and the liver cirrhosis group received 50 mg/kg DEN i.p.
twice a week for 12 weeks.
All animals underwent plain CT scanning, CTP, and contrast-enhanced CT scanning.
Scanning parameters were optimized by adjusting the diatrizoate concentration, the flow rate, and the delivery time.
The hemodynamics of both groups was further compared using optimized multislice spiral CTP imaging.
Results.
High-quality CTP images were obtained with following parameters: 150 kV; 150 mAs; 5 mm thickness, 5 mm interval; pitch, 1; matrix, 512×512; and FOV, 9.6 cm.
Compared to the control group, the liver cirrhosis group had a significantly increased value of the hepatic arterial fraction and the hepatic artery perfusion (P<0.05) but significantly decreased hepatic portal perfusion and mean transit time (P<0.05).
Conclusion.
Multislice spiral CTP imaging can be used to evaluate the hemodynamic changes in the rat model of liver cirrhosis with precancerous lesions.
American Psychological Association (APA)
Ma, Guo-Lin& Bai, Rongjie& Jiang, Huijie& Hao, Xuejia& Ling, Zaisheng& Li, Kefeng. 2013. Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030949
Modern Language Association (MLA)
Ma, Guo-Lin…[et al.]. Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030949
American Medical Association (AMA)
Ma, Guo-Lin& Bai, Rongjie& Jiang, Huijie& Hao, Xuejia& Ling, Zaisheng& Li, Kefeng. Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030949