The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease
Joint Authors
Grimm, Marcus O. W.
Zimmer, Valerie C.
Lehmann, Johannes
Hartmann, Tobias
Grimm, Heike S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder currently affecting over 35 million people worldwide.
Pathological hallmarks of AD are massive amyloidosis, extracellular senile plaques, and intracellular neurofibrillary tangles accompanied by an excessive loss of synapses.
Major constituents of senile plaques are 40–42 amino acid long peptides termed β-amyloid (Aβ).
Aβ is produced by sequential proteolytic processing of the amyloid precursor protein (APP).
APP processing and Aβ production have been one of the central scopes in AD research in the past.
In the last years, lipids and lipid-related issues are more frequently discussed to contribute to the AD pathogenesis.
This review summarizes lipid alterations found in AD postmortem brains, AD transgenic mouse models, and the current understanding of how lipids influence the molecular mechanisms leading to AD and Aβ generation, focusing especially on cholesterol, docosahexaenoic acid (DHA), and sphingolipids/glycosphingolipids.
American Psychological Association (APA)
Grimm, Marcus O. W.& Zimmer, Valerie C.& Lehmann, Johannes& Grimm, Heike S.& Hartmann, Tobias. 2014. The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease. BioMed Research International،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1030952
Modern Language Association (MLA)
Grimm, Marcus O. W.…[et al.]. The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease. BioMed Research International No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1030952
American Medical Association (AMA)
Grimm, Marcus O. W.& Zimmer, Valerie C.& Lehmann, Johannes& Grimm, Heike S.& Hartmann, Tobias. The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1030952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030952