Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle
Joint Authors
Stocco, Rita de Cassia
Martano, Manuela
Maiolino, Paola
Borzacchiello, Giuseppe
Russo, Valeria
Paciello, Orlando
Iovane, Valentina
Leonardi, Leonardo
Restucci, Brunella
Papparella, Serenella
Roperto, Sante
Roperto, Franco Peppino
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This report describes the histopathology of two hundred and fifty-three mesenchymal tumors of the urinary bladder in cattle grazing on lands rich in bracken fern.
Approximately 80% were hemangiomas and angiosarcomas.
Hemangioma (capillary, cavernous, and large vessels) was the most frequent mesenchymal tumor and was more common than angiosarcoma.
Although the appearance of endothelial cells can vary remarkably, epithelioid angiosarcomas, often containing multinucleated cells, were the most frequent malignant vascular tumors.
Hemangiopericytoma and tumors of muscle and soft connective tissue origin, alone and/or in association with tumor-like lesions, were less frequently seen.
Furthermore, forty-five cases of intravascular papillary endothelial hyperplasia (IPEH), a lesion not previously reported in the urinary bladder of cattle, were also described.
Bovine papillomavirus type-2 DNA was amplified in tumor samples.
Forty vascular tumors were investigated by dual-labeling immunofluorescence, and, for the first time, a coexpression of E5 and platelet-derived growth factor β receptor (PDGFβR) was shown to occur.
The results show that the BPV-2 E5 oncoprotein binds to the activated form of the PDGFβ receptor thus playing an important role in mesenchymal as well as epithelial carcinogenesis of the urinary bladder.
Furthermore, these findings demonstrate that BPV-2 infects both epithelial and mesenchymal cells.
American Psychological Association (APA)
Martano, Manuela& Roperto, Franco Peppino& Stocco, Rita de Cassia& Russo, Valeria& Borzacchiello, Giuseppe& Paciello, Orlando…[et al.]. 2013. Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030954
Modern Language Association (MLA)
Martano, Manuela…[et al.]. Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030954
American Medical Association (AMA)
Martano, Manuela& Roperto, Franco Peppino& Stocco, Rita de Cassia& Russo, Valeria& Borzacchiello, Giuseppe& Paciello, Orlando…[et al.]. Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030954